Name: Donor Horse Serum - EU Origin
Brand: SeamlessBio
Availability: InStock
Rating: 4.9 (18 reviews)

What is Donor Horse Serum?

Donor Horse Serum (DHS) is a premium-grade equine serum collected from healthy horses maintained in strictly controlled donor herds. Unlike standard horse serum sourced from general populations or slaughterhouses, donor horse serum ensures exceptional batch-to-batch consistency, minimal variability, and superior quality control.

Our Donor Horse Serum is sourced from EU-origin herds where animals receive regular veterinary care, controlled diets, and health screenings. This makes DHS ideal for sensitive cell culture applications, vaccine production, and research where reproducibility is critical.

                ⚡ Key Advantage: Donor herds consist of gelded draft horses (castrated males) to minimize hormone-level variations between batches, ensuring consistent performance in your experiments.
            

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Donor Horse Serum vs. Normal Horse Serum: What's the Difference?

Feature	Donor Horse Serum	Normal Horse Serum
Source	Controlled donor herds (EU)	General population or slaughterhouses
Batch Consistency	✓ High – Same donor animals	Variable – Different sources
Hormone Levels	✓ Minimized (gelded horses)	Variable (mixed genders)
Health Screening	✓ Regular veterinary inspections	Limited or none
EIA Testing	✓ Routinely tested (Coggins test)	Often not tested
Diet Control	✓ Standardized feeding protocols	Uncontrolled
Ideal For	Cell culture, vaccine production, stem cells	Immunoassays, blocking buffer, diagnostics
Price	Premium	Standard

Recommendation: Choose Donor Horse Serum when batch consistency and minimal variability are critical. For general immunoassays or blocking applications, our standard Horse Serum offers excellent value.

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Premium Product Features

🏆 Controlled Donor Herds

Sourced exclusively from veterinary-inspected EU herds with standardized care protocols and regular health monitoring.

🔬 Sterile Filtered (0.2 µm)

Triple-pass sterile filtration ensures complete removal of bacteria and particulates while preserving growth factors.

✅ EIA Tested

Every batch is tested for Equine Infectious Anemia (EIA) using the Coggins test for maximum safety.

📊 Low Hemoglobin

Pre-collection fasting protocols ensure minimal hemoglobin contamination (<25 mg/dL).

🎯 Batch Consistency

Gelded draft horses minimize hormone variability, ensuring reproducible results across experiments.

📜 ISO 13485 Certified

Manufactured under cGMP conditions with full documentation (COA, COO, MSDS) for regulatory compliance.

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Technical Specifications & Quality Control

Product Specifications

Origin: European Union (EU)

Source Animals: Gelded draft horses >12 months

Filtration: 0.2 µm sterile filtered

Hemoglobin: <25 mg/dL

Total Protein: 6.0-8.5 g/dL

pH: 7.0-8.0

Osmolality: 280-320 mOsm/kg

Endotoxin: <10 EU/mL

Quality Testing Performed on Every Batch

Test	Method	Specification
Sterility	14-day USP test	Negative
Mycoplasma	PCR & culture	Negative
EIA (Equine Infectious Anemia)	Coggins test	Negative
Endotoxin	LAL assay	<10 EU/mL
Hemoglobin	Spectrophotometry	<25 mg/dL
Total Protein	Bradford assay	6.0-8.5 g/dL
Growth Promotion	Cell proliferation assay	Pass (Sp2/O cells)

                📋 Complete Documentation: Every batch includes Certificate of Analysis (COA), Certificate of Origin (COO), and Material Safety Data Sheet (MSDS) for full traceability and regulatory compliance.
            

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Applications of Donor Horse Serum in Research & Production

🧬 Cell Culture Media Supplement

Supports growth of mammalian cells including hybridomas, CHO, HEK293, and Vero cells. Cost-effective alternative to FBS with high protein content.

💉 Vaccine & Viral Vector Production

Ideal for vaccine manufacturing and viral vector production where bovine antibodies would interfere with assays or therapeutic outcomes.

🔬 Hematopoietic Stem Cell Culture

Contains unique growth factors that specifically support hematopoietic progenitor cells and myeloid cell differentiation.

🧠 Neuronal Cell Culture

Proven effectiveness in primary cortical neuron cultures, neuronal differentiation, and brain slice culture maintenance.

🦠 Bovine Virus Research

Essential for bovine virus studies as it contains no bovine antibodies that could neutralize viral particles or interfere with detection.

🧪 Mycoplasma Culture Media

Widely used as supplement in mycoplasma growth and detection media for diagnostic applications.

🔎 Diagnostic Assay Development

Suitable for development and optimization of diagnostic immunoassays, ELISA protocols, and quality control procedures.

💪 Myogenesis Studies

Supports skeletal muscle cell differentiation and myotube formation in regenerative medicine research.

                💡 Did You Know? Horse serum contains approximately twice the protein content of FBS but lower levels of certain trace elements. For optimal results, consider supplementing your basal medium with trace elements when switching from FBS to horse serum.
            

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Available Treatment Options

Standard Donor Horse Serum (Sterile Filtered)

Our default product is sterile filtered (0.2 µm), which preserves all growth factors, hormones, and proteins while ensuring complete sterility. This is the recommended option for most cell culture applications.

Heat-Inactivated Donor Horse Serum

Heat inactivation (56°C, 30 minutes) inactivates complement factors in the serum. This treatment is beneficial for:

Immunological assays where complement interference is problematic
Antibody production and neutralization studies
Virus propagation where complement-mediated lysis must be avoided
Detection of neutralizing antibodies in diagnostic applications

                ⚠️ Important Note: Heat inactivation may reduce levels of heat-sensitive growth factors. We recommend testing both heat-inactivated and non-heat-inactivated serum to determine which performs best for your specific cell line and application.
            

Custom Treatment Options

Additional treatments available upon request:

Gamma irradiation: For enhanced viral safety in GMP production
Charcoal-stripped: For hormone-sensitive applications
Delipidized: Reduced lipid content for specific assays
Custom filtration: 0.1 µm or other specifications

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Packaging Sizes & Ordering Information

Standard Packaging Sizes

100 mL Standard laboratory size

500 mL Most popular for routine use

1000 mL (1 L) Economic choice for high-volume users

Bulk Volumes 5 L, 10 L, 20 L available on request

Custom Packaging

We can accommodate special packaging requirements including:

Custom aliquot sizes (e.g., 50 mL, 250 mL)
Specific container types (bottles, bags)
Private labeling for distributors
Pooled lots for maximum consistency across large studies

Storage & Handling

Long-term storage: Store at -20°C or -80°C for up to 10 years
After thawing: Store at 2-8°C and use within 4 weeks
Thawing: Overnight at 2-8°C or in 37°C water bath with gentle swirling
Important: Avoid repeated freeze-thaw cycles

                🚚 Fast Delivery: All orders ship on dry ice with temperature monitoring. Express delivery available for urgent orders.
            

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Frequently Asked Questions

Why choose Donor Horse Serum over standard Horse Serum?

Donor Horse Serum offers superior batch-to-batch consistency because it comes from the same controlled herd of animals with standardized diets and health protocols. This minimizes experimental variability - critical for long-term studies, vaccine production, and regulatory submissions. Standard horse serum, while more economical, may have higher variability between lots.

Can I use Donor Horse Serum instead of FBS in my protocols?

Yes, in many applications. Horse serum is a cost-effective FBS alternative with similar growth-promoting properties. However, it has approximately half the growth factors but twice the protein content of FBS. You may need to optimize concentrations (typically 10-20% vs. 10% FBS) and potentially supplement trace elements. We recommend side-by-side testing before switching completely.

Is your Donor Horse Serum suitable for GMP production?

Yes. Our Donor Horse Serum is manufactured under cGMP conditions and is ISO 13485 certified. Each batch includes complete documentation (COA, COO, MSDS) with full traceability to the source animals. All donor horses undergo regular veterinary inspections and EIA testing, meeting requirements for use in regulated manufacturing environments.

What is EIA testing and why is it important?

EIA (Equine Infectious Anemia) is a viral disease affecting horses. The Coggins test screens for EIA antibodies. All our donor horses are routinely tested to ensure they're disease-free, providing an additional safety layer for your cell culture work. Note: Donor horses may be vaccinated for rabies, so rabies antibodies might be present - this does not affect serum quality or performance.

Should I use heat-inactivated or non-heat-inactivated serum?

Use non-heat-inactivated (standard sterile filtered) unless you specifically need to eliminate complement activity. Heat inactivation is beneficial for immunological assays, antibody production, and virus work where complement could interfere. However, it may reduce some heat-sensitive growth factors. Most cell culture applications work well with non-heat-inactivated serum.

Can I request a sample for testing?

Yes! We offer sample programs for qualified research institutions and commercial labs. Contact our team at info@seamlessbio.de or through the shop to request a test sample with complete COA documentation.

How does horse serum perform with hematopoietic cells?

Excellent! Horse serum contains unique phospholipase A2 products and growth factors that specifically support hematopoietic stem cells and myeloid cell differentiation - factors often lacking in other sera types. This makes it particularly valuable for blood cell research and hematopoietic stem cell expansion.

What makes your EU-origin serum different from US or other origins?

EU-origin horses are subject to strict European veterinary standards and animal welfare regulations. Our controlled donor herds are maintained in compliance with EU regulations, ensuring high ethical standards and consistent quality. For customers in Europe, EU-origin also simplifies import documentation and regulatory compliance.

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Why Choose SeamlessBio for Your Donor Horse Serum?

🏅 Quality Assurance

ISO 9001 and ISO 13485 certified manufacturing with rigorous testing protocols and full batch documentation.

🔬 Expert Support

Technical team with deep cell culture expertise available to help optimize your protocols and troubleshoot issues.

📦 Reliable Supply

Established relationships with EU donor herds ensure consistent supply and lot availability for long-term projects.

⚡ Fast Delivery

Most orders ship within 1-2 business days on dry ice with temperature monitoring. Express options available.

💰 Competitive Pricing

Volume discounts available. Request quotes for bulk orders or long-term supply agreements.

🎯 Custom Solutions

Special treatments, custom packaging, pooled lots, and private labeling available to meet your specific needs.

Donor Horse Serum – EU Origin