Human Serum Type AB Off-the-Clot — Universal Donor + Max Growth Factors | SeamlessBio
Human Serum Type AB, Off-the-Clot — Universal Donor with Maximum Growth Factors
Human Serum Type AB Off-the-Clot combines two critical properties: the universal donor blood type (AB — no anti-A/B antibodies) with the maximum growth factor content of the off-the-clot collection method. The result is a serum that does not interfere with cell surface antigens of any blood type, while simultaneously providing the full spectrum of platelet-derived growth factors released during natural coagulation.
Three Properties Combined
| Property | Source | Benefit |
|---|
| Type AB | Donor blood group selection | No anti-A or anti-B antibodies — compatible with cells of all blood types, no blood-group interference in assays |
| Off-the-Clot | Collection without anticoagulants | Maximum PDGF, EGF, TGF-β, IGF-1 from platelet degranulation — highest proliferative support |
| Mixed donors | Multiple qualified donors per lot | Pooled lot composition — broader factor diversity than single-donor products |
Key Applications
| Application | Why AB OTC? |
|---|
| Plasmodium falciparum culture | AB prevents lysis of infected erythrocytes (A/B antigens on RBC surface); OTC provides growth factors for parasite culture maintenance |
| Human stem cell expansion (general) | AB eliminates blood-group lysis risk; OTC growth factors (EGF, IGF-1) support stem cell proliferation |
| Universal cell culture supplement | AB serum can be used with cells of any blood type — no need to match serum blood type to cell line |
| Diagnostic assay matrix development | AB matrix + high protein content from OTC collection provides the most representative human serum matrix for IVD development |
Specifications
| Parameter | Specification |
|---|
| Blood type | AB — confirmed anti-A and anti-B negative |
| Donor pool | Mixed gender (male and female) |
| Collection method | Off-the-clot — natural coagulation, no anticoagulants |
| Processing | Heat inactivated, gamma irradiated, or native — specify on order |
| Filtration | 0.2 µm sterile filtered |
| Origin | EU and/or US |
| Volumes | 100 mL, 500 mL | Bulk on request |
| Documentation | CoA, CoO, MSDS |
Complete Human Serum Portfolio
| Product | Blood Type | Donor | Processing | Primary Use | Order |
|---|
| Human Serum | Mixed | Mixed | HI or GI | General cell culture, diagnostics | Shop → |
| Human Serum, Male | Mixed | Male only | HI or GI | Hormone-controlled cell culture | Shop → |
| Human Serum, Type AB | AB | Mixed | HI or GI | Immunoassays, diagnostics | Shop → |
| Human Serum Type AB, Male | AB | Male only | HI or GI | Cell therapy R&D, immune assays | Shop → |
| Human Serum Off-the-Clot | Mixed | Mixed | OTC | Growth factor-rich cell culture | Shop → |
| Human Serum Type AB, Off-the-Clot | AB | Mixed | OTC | Universal donor, growth factor-rich | Shop → |
| Human Serum Type AB, Male OTC | AB | Male only | OTC | CAR-T, NK cells, ATMP — gold standard | Shop → |
Order Human Serum Type AB Off-the-Clot
Request free test volume
Contact: info@seamlessbio.de | +49 851 37932226
