Human Serum Type AB from male donors combines the two most important serum quality attributes for cell therapy and immunological applications: the universal blood type (AB — no anti-A/B antibodies) and the reproducibility advantage of male-only donors (no hormonal variability, no TRALI risk). This combination makes AB Male serum the optimal choice for applications requiring both minimal immunoreactivity and maximum lot-to-lot consistency.
| Property | Benefit |
|---|
| Type AB — no anti-A/B antibodies | No blood-group-mediated cell lysis or assay interference. Compatible with cells of all blood types. |
| Male donors only — no hormonal variation | Eliminates oestradiol/progesterone fluctuation that affects cell proliferation and differentiation outcomes. |
| Male donors — no anti-HLA antibodies | Eliminates TRALI risk. No activation of T cells by alloantibodies from previously pregnant donors. |
| Combined: lowest immunoreactivity | Preferred ancillary material for GMP cell therapy per EMA guidelines and Ph. Eur. 5.2.12. |
| Application | Protocol notes |
|---|
| Immunological research (T cell, B cell, NK cell assays) | AB eliminates blood-group interference; male donors eliminate hormone-driven variability in immune cell responses |
| Vaccine development (antibody assays) | AB matrix prevents blood-group-specific background in neutralisation and ELISA formats; male donors improve lot consistency |
| Diagnostic kit development (IVDR) | AB male serum as standard negative control matrix in serology ELISA — ISO 13485 lot documentation available |
| Primary human immune cell culture | AB male serum provides a physiologically matched, immunologically neutral supplement for PBMC, T cell, dendritic cell culture |
| Tissue engineering | AB male serum supports fibroblast, keratinocyte, chondrocyte culture in xeno-free tissue graft systems |
| Product | Blood Type | Donor | Processing | Primary Use | Order |
|---|
| Human Serum | Mixed | Mixed | HI or GI | General cell culture, diagnostics | Shop → |
| Human Serum, Male | Mixed | Male only | HI or GI | Hormone-controlled cell culture | Shop → |
| Human Serum, Type AB | AB | Mixed | HI or GI | Immunoassays, diagnostics | Shop → |
| Human Serum Type AB, Male | AB | Male only | HI or GI | Cell therapy R&D, immune assays | Shop → |
| Human Serum Off-the-Clot | Mixed | Mixed | OTC | Growth factor-rich cell culture | Shop → |
| Human Serum Type AB, Off-the-Clot | AB | Mixed | OTC | Universal donor, growth factor-rich | Shop → |
| Human Serum Type AB, Male OTC | AB | Male only | OTC | CAR-T, NK cells, ATMP — gold standard | Shop → |
