Monkey Serum — Rhesus & Cynomolgus
SeamlessBio supplies non-human primate (NHP) serum from two species — Rhesus Macaque (Macaca mulatta) and Cynomolgus Monkey (Macaca fascicularis) — from US-origin donors. Sterile filtered, screened for key NHP pathogens, suitable for cell culture, blocking, preclinical research and immunology studies. Available from EU stock with no minimum order quantity.
Two Species — One Supplier
Rhesus Monkey Serum
Macaca mulatta · US origin
Collected from US-origin Rhesus Macaques — the most widely used NHP model in biomedical research. Rhesus serum is the reference standard for NHP-based preclinical studies, vaccine research and immunology assays requiring primate-specific matrix material.
Origin: US · Sterile filtered (0.2 µm) · No haemolysis
Screening: Herpes B Virus, SIV, SRV, STLV, retroviruses — negative
Storage: −20°C · Heat inactivation available on request
Available: 100 ml, 500 ml · Larger volumes on request
Cynomolgus Monkey Serum
Macaca fascicularis · US origin
Cynomolgus (Crab-eating Macaque) serum from US-origin donors. The preferred NHP serum for antibody blocking applications, cell culture supplementation and preclinical drug studies — particularly in oncology, immunology and neuroscience research.
Origin: US · Sterile filtered (0.2 µm) · No haemolysis
Screening: Herpes B Virus, SIV, SRV, STLV, retroviruses — negative
Storage: −20°C · Heat inactivation available on request
Available: 100 ml, 500 ml · Larger volumes on request
Applications
NHP serum is used wherever research requires a primate biological matrix closer to human than standard animal sera — particularly where cross-reactivity with human antibodies or human-relevant receptor binding is being studied.
| Application | Species | Notes |
|---|---|---|
| Antibody blocking (IHC, IF, ELISA) | Cynomolgus or Rhesus | Blocks non-specific antibody binding in primate tissue sections |
| Cell culture supplementation | Cynomolgus preferred | Provides macromolecules, growth factors, carrier proteins for NHP-origin cell lines |
| Preclinical drug safety studies | Cynomolgus preferred | Matrix-matched controls for pharmacokinetic assays in cyno drug development programs |
| Vaccine development | Rhesus or Cynomolgus | NHP serum matrix for immune response assays; species-specific complement |
| Biomarker research | Both | Reference matrix for NHP biomarker validation studies |
| Immunology assays | Both | Species-matched serum for ADCC, cytokine release, T/B cell proliferation assays |
| Neuroscience research | Cynomolgus | Preferred NHP model for neurological disease research including CNS studies |
| HIV / AIDS research | Cynomolgus | SIV model studies, AIDS pathogenesis, therapeutic drug evaluation |
| Stem cell research | Both | Neural stem cells, embryonic stem cells, bone marrow MSC research in NHP models |
Rhesus vs. Cynomolgus — Which to Choose?
- Your research protocol uses Rhesus as the animal model
- Vaccine immunogenicity studies in Rhesus model
- Cardiovascular or metabolic disease research
- Historical precedent — your SOP specifies Rhesus
- Antibody blocking in IHC on primate tissue
- Preclinical drug safety — cyno is the standard NHP model
- Oncology, immunology or neuroscience cell culture
- HIV / SIV research, AIDS pathogenesis
Specifications
| Parameter | Rhesus Monkey Serum | Cynomolgus Monkey Serum |
|---|---|---|
| Species | Macaca mulatta | Macaca fascicularis |
| Donor origin | US origin | US origin |
| Collection | Whole blood, serum separation by centrifugation | Whole blood, serum separation by centrifugation |
| Processing | Sterile filtered (0.2 µm) | Sterile filtered (0.2 µm) |
| Haemolysis | None / minimal | None / minimal |
| Pathogen screening | Herpes B Virus, SIV, SRV, STLV, retroviruses — negative | Herpes B Virus, SIV, SRV, STLV, retroviruses — negative |
| Heat inactivation | Available on request | Available on request |
| Storage | −20°C, max 3 freeze-thaw cycles | −20°C, max 3 freeze-thaw cycles |
| Documentation | COA per lot | COA per lot |
| Available volumes | 100 ml, 500 ml; larger on request | 100 ml, 500 ml; larger on request |
| Minimum order | No minimum order quantity | No minimum order quantity |
| Batch reservation | Available | Available |
Frequently Asked Questions
What is monkey serum used for in research?
Monkey serum has two main applications: (1) as a cell culture supplement for NHP-derived cell lines and in research where primate-relevant growth factors are required, and (2) as a blocking reagent in antibody-based applications (IHC, IF, ELISA) where non-specific binding from primate cross-reactivity must be suppressed. Cynomolgus serum is the standard for most preclinical drug safety programs.
What is the difference between Rhesus and Cynomolgus monkey serum?
Both are macaque species with high genetic similarity to humans, but they differ in their use in research. Rhesus (Macaca mulatta) is the traditional NHP model for vaccine research, cardiovascular studies and reproductive biology. Cynomolgus (Macaca fascicularis) has become the preferred species for preclinical drug safety assessment because it is more readily available, smaller and easier to work with. For antibody blocking, both are used — match the species to the tissue or cell line you are working with.
Is CITES documentation required for EU import?
Yes — both Rhesus and Cynomolgus monkeys are listed under CITES Appendix II. Biological materials derived from CITES-listed species require appropriate import documentation when crossing international borders into the EU. SeamlessBio provides full CITES import documentation for EU customers as standard. Contact us at info@seamlessbio.de before ordering to confirm the requirements for your specific country.
Is heat inactivated monkey serum available?
Yes — heat inactivated (56°C / 30 min) versions of both Rhesus and Cynomolgus serum are available on request. Heat inactivation inactivates complement while preserving immunoglobulins and most growth factors. Contact us at info@seamlessbio.de to order.
Can I get a test sample before ordering?
Yes — test samples are available on request. Contact us at info@seamlessbio.de or +49 851 37932226. Batch reservation is available without prepayment once you have validated a lot in your system.
Related Products
Order or request a sample
Rhesus and Cynomolgus monkey serum from EU stock. No minimum order. Full CITES documentation. Batch reservation available.