For decades, Fetal Bovine Serum (FBS) has been the gold standard in cell culture.
But as research advances and regulatory requirements increase, scientists are looking for animal-free, reproducible alternatives.
One solution gaining traction in stem cell research and regenerative medicine is Human Platelet Lysate (hPL).
What is Human Platelet Lysate (hPL)?
Human Platelet Lysate is a serum supplement derived from human platelets.
It contains a rich mix of growth factors and cytokines, making it highly effective for cell expansion and differentiation – especially for mesenchymal stem cells (MSCs).
Unlike FBS, hPL is:
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✅ Animal-free (xeno-free)
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✅ Produced under cGMP & ISO standards
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✅ More physiologically relevant for human applications
hPL vs. FBS – Key Differences
| Features | FBS | hPL (Human Platelet Lysate) |
|---|---|---|
| Source | Fetal bovine | Human blood |
| Ethical considerations | Animal-derived | Animal-free, ethically sourced |
| Regulatory acceptance | Limited in clinical use | Preferred for clinical applications |
| Endotoxin levels | Variable | Low / very low endotoxin |
| Applications | General cell culture | Stem cell research, regenerative medicine, immunotherapy |
Applications of hPL in Stem Cell Research
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Mesenchymal stem cell expansion (MSCs)
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Regenerative medicine & tissue engineering
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Cell therapy development (e.g. CAR-T)
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Immunotherapy & translational medicine
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Bioprocessing in GMP environments
hPL not only supports cell growth – it ensures consistency and reproducibility, which are essential for scaling research into clinical applications.
Why Reproducibility Matters
One of the biggest challenges in stem cell research is variability.
Switching from FBS to cGMP-certified Human Platelet Lysate reduces:
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Batch-to-batch differences
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Ethical/regulatory hurdles
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Risk of inconsistent results
This makes hPL a strong candidate for future-proofing stem cell workflows.
SeamlessBio – Your Supplier for Human Platelet Lysate
At SeamlessBio, we supply cGMP-compliant hPL with:
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📄 Full documentation (COA, COO, MSDS)
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🌍 Ethically sourced materials
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🧪 Batch-to-batch consistency for reproducible results
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📦 Flexible packaging & bulk supply
With SeamlessBio, you get not just a product, but a trusted partner for stem cell research and regenerative medicine.
Request Your hPL Sample Today
Curious to experience the benefits of hPL over FBS?
📩 Contact us today to request your sample volume of Human Platelet Lysate (more informations).
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